This title appears in the Scientific Report :
2019
Please use the identifier:
http://dx.doi.org/10.1103/PhysRevE.99.012405 in citations.
Please use the identifier: http://hdl.handle.net/2128/22701 in citations.
Stationary RNA polymerase fluctuations during transcription elongation
Stationary RNA polymerase fluctuations during transcription elongation
We study fluctuation effects of nonsteric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track during transcription elongation. Based on a stochastic model that allows for the exact analytical computation of the stationary distribution of RNAPs a...
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Personal Name(s): | Belitsky, V. (Corresponding author) |
---|---|
Schütz, G. M. | |
Contributing Institute: |
Theorie der Weichen Materie und Biophysik; ICS-2 |
Published in: | Physical Review E Physical review / E, 99 99 (2019 2019) 1 1, S. 012405 012405 |
Imprint: |
Woodbury, NY
Inst.
2019
2019-01-07 2019-01-01 |
DOI: |
10.1103/PhysRevE.99.012405 |
PubMed ID: |
30780341 |
Document Type: |
Journal Article |
Research Program: |
Functional Macromolecules and Complexes |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/22701 in citations.
We study fluctuation effects of nonsteric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track during transcription elongation. Based on a stochastic model that allows for the exact analytical computation of the stationary distribution of RNAPs as a function of their density, interaction strength, nucleoside triphosphate concentration, and rate of pyrophosphate release we predict an almost geometric headway distribution of subsequent RNAP transcribing on the same DNA segment. The localization length which characterizes the decay of the headway distribution depends directly only the average density of RNAP and the interaction strength, but not on specific single-RNAP properties. Density correlations are predicted to decay exponentially with the distance (in units of DNA base pairs), with a correlation length that is significantly shorter than the localization length. |