This title appears in the Scientific Report :
2019
Please use the identifier:
http://hdl.handle.net/2128/24009 in citations.
Please use the identifier: http://dx.doi.org/10.3390/molecules24214008 in citations.
Halogenating Enzymes for Active Agent Synthesis: First Steps are done, Many have to follow
Halogenating Enzymes for Active Agent Synthesis: First Steps are done, Many have to follow
Halogens can be very important for active agents as vital parts of their binding mode, on the one hand, but are on the other hand instrumental in the synthesis of most active agents. However, the primary halogenating compound is molecular chlorine which has two major drawbacks, high energy consumpti...
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Personal Name(s): | Fejzagic, Alexander |
---|---|
Gebauer, Jan / Huwa, Nikolai / Classen, Thomas (Corresponding author) | |
Contributing Institute: |
Institut für Bioorganische Chemie (HHUD); IBOC Biotechnologie; IBG-1 |
Published in: | Molecules, 24 (2019) 21, S. 4008 - |
Imprint: |
Basel
MDPI
2019
|
PubMed ID: |
31694313 |
DOI: |
10.3390/molecules24214008 |
Document Type: |
Journal Article |
Research Program: |
Mechanismen der durch Dirigent/Jacalin-Proteinpaare hervorgerufenen Breitspektrumresistenz in Pflanzen gegen pilzliche Pathogene Innovative Synergisms |
Link: |
Get full text Get full text OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.3390/molecules24214008 in citations.
Halogens can be very important for active agents as vital parts of their binding mode, on the one hand, but are on the other hand instrumental in the synthesis of most active agents. However, the primary halogenating compound is molecular chlorine which has two major drawbacks, high energy consumption and hazardous handling. Nature bypassed molecular halogens and evolved at least six halogenating enzymes: Three kind of haloperoxidases, flavin-dependent halogenases as well as α-ketoglutarate and S-adenosylmethionine (SAM)-dependent halogenases. This review shows what is known today on these enzymes in terms of biocatalytic usage. The reader may understand this review as a plea for the usage of halogenating enzymes for fine chemical syntheses, but there are many steps to take until halogenating enzymes are reliable, flexible, and sustainable catalysts for halogenation. |