This title appears in the Scientific Report :
2020
Please use the identifier:
http://hdl.handle.net/2128/25869 in citations.
Please use the identifier: http://dx.doi.org/10.1111/ejn.14690 in citations.
Neuroanatomy of dyslexia: An allometric approach
Neuroanatomy of dyslexia: An allometric approach
Despite evidence for a difference in total brain volume between dyslexic and good readers, no previous neuroimaging study examined differences in allometric scaling (i.e. differences in the relationship between regional and total brain volumes) between dyslexic and good readers. The present study ai...
Saved in:
Personal Name(s): | Peyre, Hugo (Corresponding author) |
---|---|
Mohanpuria, Neha / Jednoróg, Katarzyna / Heim, Stefan / Grande, Marion / van Ermingen-Marbach, Muna / Altarelli, Irene / Monzalvo, Karla / Williams, Camille / Germanaud, David / Toro, Roberto / Ramus, Franck | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | European journal of neuroscience, 52 (2020) 6, S. 3595-3609 |
Imprint: |
Oxford [u.a.]
Blackwell
2020
|
PubMed ID: |
31991019 |
DOI: |
10.1111/ejn.14690 |
Document Type: |
Journal Article |
Research Program: |
Connectivity and Activity |
Link: |
Published on 2020-01-28. Available in OpenAccess from 2021-01-28. Get full text Published on 2020-01-28. Available in OpenAccess from 2021-01-28. Get full text |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1111/ejn.14690 in citations.
Despite evidence for a difference in total brain volume between dyslexic and good readers, no previous neuroimaging study examined differences in allometric scaling (i.e. differences in the relationship between regional and total brain volumes) between dyslexic and good readers. The present study aims to fill this gap by testing differences in allometric scaling and lobar brain volume differences in dyslexic and good readers. Object-based morphometry analysis was used to determine grey and white matter volumes of the 4 lobes, the cerebellum, and limbic structures in 130 dyslexic and 106 good readers aged 8 to 14 years. Data were collected across three countries (France, Poland, and Germany). Three methodological approaches were used: Principal Components Analysis (PCA), linear regression, and Multiple Group Confirmatory Factor Analysis (MGCFA). Difference in total brain volume between good and dyslexic readers was Cohen's d=0.39. We found no difference in allometric scaling, nor in regional brain volume between dyslexic and good readers. Results of our three methodological approaches (PCA, linear regression and MGCFA) were consistent. This study provides evidence for total brain volume differences between dyslexic and control children, but no evidence for differences in the volumes of the four lobes, the cerebellum or limbic structures, once allometry is properly taken into account. It also finds no evidence for a difference in allometric relationships between the groups. We highlight the methodological interest of the MGCFA approach to investigate such research issues. |