This title appears in the Scientific Report :
2020
Please use the identifier:
http://dx.doi.org/10.1093/schbul/sbaa016 in citations.
Please use the identifier: http://hdl.handle.net/2128/25764 in citations.
Compression of cerebellar functional gradients in schizophrenia
Compression of cerebellar functional gradients in schizophrenia
Our understanding of cerebellar involvement in brain disorders has evolved from motor processing to high-level cognitive and affective processing. Recent neuroscience progress has highlighted hierarchy as a fundamental principle for the brain organization. Despite substantial research on cerebellar...
Saved in:
Personal Name(s): | Dong, Debo |
---|---|
Luo, Cheng (Corresponding author) / Guell, Xavier / Wang, Yulin / He, Hui / Duan, Mingjun / Eickhoff, Simon / Yao, Dezhong (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Schizophrenia bulletin, 46 (2020) 5, S. 1282–1295 |
Imprint: |
Oxford
Oxford Univ. Press
2020
|
DOI: |
10.1093/schbul/sbaa016 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
Restricted Restricted Restricted Restricted Published on 2020-03-07. Available in OpenAccess from 2021-03-07. Restricted Restricted Published on 2020-03-07. Available in OpenAccess from 2021-03-07. |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/25764 in citations.
Our understanding of cerebellar involvement in brain disorders has evolved from motor processing to high-level cognitive and affective processing. Recent neuroscience progress has highlighted hierarchy as a fundamental principle for the brain organization. Despite substantial research on cerebellar dysfunction in schizophrenia, there is a need to establish a neurobiological framework to better understand the co-occurrence and interaction of low- and high-level functional abnormalities of cerebellum in schizophrenia. To help to establish such a framework, we investigated the abnormalities in the distribution of sensorimotor-supramodal hierarchical processing topography in the cerebellum and cerebellar-cerebral circuits in schizophrenia using a novel gradient-based resting-state Functional-connectivity(FC) analysis (96 patients with schizophrenia vs. 120 healthy controls). We found schizophrenia patients showed a compression of the principal motor-to-supramodal gradient. Specifically, there were increased gradient values in sensorimotor regions and decreased gradient values in supramodal regions, resulting in a shorter distance (compression) between the sensorimotor and supramodal poles of this gradient. This pattern was observed in intra-cerebellar, cerebellar-cerebral, and cerebral-cerebellar FC. Further investigation revealed hyper-connectivity between sensorimotor and cognition areas within cerebellum, between cerebellar sensorimotor and cerebral cognition areas, and between cerebellar cognition and cerebral sensorimotor areas, possibly contributing to the observed compressed pattern. These findings present a novel mechanism that may underlie the co-occurrence and interaction of low- and high-level functional abnormalities of cerebellar and cerebro-cerebellar circuits in schizophrenia. Within this framework of abnormal motor-to-supramodal organization, a cascade of impairments stemming from disrupted low-level sensorimotor system may in part account for high-level cognitive cerebellar dysfunction in schizophrenia.Keywords: Schizophrenia; Sensorimotor; Cerebellum; Cerebellar-cerebral Circuits; Resting-state Functional connectivity; Functional Gradient |