This title appears in the Scientific Report :
2020
Please use the identifier:
http://hdl.handle.net/2128/25630 in citations.
Please use the identifier: http://dx.doi.org/10.1039/D0CC02223C in citations.
Preparation of labeled aromatic amino acids via late-stage 18 F-fluorination of chiral nickel and copper complexes
Preparation of labeled aromatic amino acids via late-stage 18 F-fluorination of chiral nickel and copper complexes
A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially...
Saved in:
Personal Name(s): | Craig, Austin |
---|---|
Kolks, Niklas / Urusova, Elizaveta / Zischler, Johannes / Brugger, Melanie / Endepols, Heike / Neumaier, Bernd (Corresponding author) / Zlatopolskiy, Boris D. | |
Contributing Institute: |
Nuklearchemie; INM-5 |
Published in: | Chemical communications, 56 (2020) 66, S. 9505 - 9508 |
Imprint: |
Cambridge
Soc.
2020
|
DOI: |
10.1039/D0CC02223C |
PubMed ID: |
32686800 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Link: |
Published on 2020-07-09. Available in OpenAccess from 2021-07-09. Restricted Published on 2020-07-09. Available in OpenAccess from 2021-07-09. Restricted |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1039/D0CC02223C in citations.
A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules. |