This title appears in the Scientific Report :
2020
Please use the identifier:
http://dx.doi.org/10.1016/j.chembiol.2020.08.005 in citations.
Please use the identifier: http://hdl.handle.net/2128/26847 in citations.
Photocontrol of Endogenous Glycine Receptors In Vivo
Photocontrol of Endogenous Glycine Receptors In Vivo
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and...
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Personal Name(s): | Gomila, Alexandre M. J. |
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Rustler, Karin / Maleeva, Galyna / Nin-Hill, Alba / Wutz, Daniel / Bautista-Barrufet, Antoni / Rovira, Xavier / Bosch, Miquel / Mukhametova, Elvira / Petukhova, Elena / Ponomareva, Daria / Mukhamedyarov, Marat / Peiretti, Franck / Alfonso-Prieto, Mercedes / Rovira, Carme (Corresponding author) / König, Burkhard (Corresponding author) / Bregestovski, Piotr (Corresponding author) / Gorostiza, Pau (Corresponding author) | |
Contributing Institute: |
Computational Biomedicine; INM-9 Computational Biomedicine; IAS-5 |
Published in: | Cell chemical biology, 27 (2020) 11, S. 1425 - 1433.e7 |
Imprint: |
Amsterdam
Elsevier
2020
|
DOI: |
10.1016/j.chembiol.2020.08.005 |
Document Type: |
Journal Article |
Research Program: |
Theory, modelling and simulation Connectivity and Activity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/26847 in citations.
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies. |