This title appears in the Scientific Report :
2020
Please use the identifier:
http://hdl.handle.net/2128/26883 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.copbio.2020.03.007 in citations.
Engineering of natural product biosynthesis in Pseudomonas putida
Engineering of natural product biosynthesis in Pseudomonas putida
Organisms from all kingdoms of life represent a rich source for valuable natural products with various applications. Microbial systems are useful to implement the expression of respective biosynthetic genes and establish the production and effective access to natural products, or to elucidate the bi...
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Personal Name(s): | Loeschcke, Anita (Corresponding author) |
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Thies, Stephan | |
Contributing Institute: |
Institut für Molekulare Enzymtechnologie (HHUD); IMET |
Published in: | Current opinion in biotechnology, 65 (2020) S. 213 - 224 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2020
|
DOI: |
10.1016/j.copbio.2020.03.007 |
Document Type: |
Journal Article |
Research Program: |
Innovative Synergisms |
Link: |
Published on 2020-06-01. Available in OpenAccess from 2021-06-01. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.copbio.2020.03.007 in citations.
Organisms from all kingdoms of life represent a rich source for valuable natural products with various applications. Microbial systems are useful to implement the expression of respective biosynthetic genes and establish the production and effective access to natural products, or to elucidate the biochemistry of the underlying pathways. Pseudomonas putida, a Gram-negative soil bacterium, appears to be particularly suitable for natural product biosynthesis because of an advantageous intrinsic metabolism and a remarkable tolerance toward various xenobiotics. This article presents the current state of engineering P. putida for the biosynthesis of rhamnolipids, terpenoids, polyketides, non-ribosomal peptides, and products from amino acid metabolism. Technological advances facilitating chromosomal integration and expression of biosynthetic genes, and smart metabolic engineering are key to success. |