This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/27456 in citations.
Please use the identifier: http://dx.doi.org/10.3390/v13030504 in citations.
Foamy Viruses, Bet, and APOBEC3 Restriction
Foamy Viruses, Bet, and APOBEC3 Restriction
Non-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called foamy viruses (FV) with zoonotic potential are...
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Personal Name(s): | Jaguva Vasudevan, Ananda Ayyappan (Corresponding author) |
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Becker, Daniel / Luedde, Tom / Gohlke, Holger / Münk, Carsten (Corresponding author) | |
Contributing Institute: |
Strukturbiochemie; IBI-7 John von Neumann - Institut für Computing; NIC Jülich Supercomputing Center; JSC |
Published in: | Viruses, 13 (2021) 3, S. 504 |
Imprint: |
Basel
MDPI
2021
|
DOI: |
10.3390/v13030504 |
Document Type: |
Journal Article |
Research Program: |
Forschergruppe Gohlke Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.3390/v13030504 in citations.
Non-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called foamy viruses (FV) with zoonotic potential are occasionally detected in bushmeat hunters or zookeepers. Various FVs are endemic in numerous mammalian natural hosts, such as primates, felines, bovines, and equines, and other animals, but not in humans. They are apathogenic, and significant differences exist between the viral life cycles of FV and other retroviruses. Importantly, FVs replicate in the presence of many well-defined retroviral restriction factors such as TRIM5α, BST2 (Tetherin), MX2, and APOBEC3 (A3). While the interaction of A3s with HIV-1 is well studied, the escape mechanisms of FVs from restriction by A3 is much less explored. Here we review the current knowledge of FV biology, host restriction factors, and FV–host interactions with an emphasis on the consequences of FV regulatory protein Bet binding to A3s and outline crucial open questions for future studies. |