This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/28165 in citations.
Please use the identifier: http://dx.doi.org/10.1002/adma.202008683 in citations.
Unravelling Magnetic Nanochain Formation in Dispersion for In Vivo Applications
Unravelling Magnetic Nanochain Formation in Dispersion for In Vivo Applications
Self-assembly of iron oxide nanoparticles (IONPs) into 1D chains is appealing, because of their biocompatibility and higher mobility compared to 2D/3D assemblies while traversing the circulatory passages and blood vessels for in vivo biomedical applications. In this work, parameters such as size, co...
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Personal Name(s): | Nandakumaran, Nileena |
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Barnsley, Lester / Feoktystov, Artem / Ivanov, Sergei A. / Huber, Dale L. / Fruhner, Lisa S. / Leffler, Vanessa / Ehlert, Sascha / Kentzinger, Emmanuel / Qdemat, Asma / Bhatnagar, Tanvi / Rücker, Ulrich / Wharmby, Michael T. / Cervellino, Antonio / Dunin-Borkowski, Rafal E. / Brückel, Thomas / Feygenson, Mikhail (Corresponding author) | |
Contributing Institute: |
Streumethoden; JCNS-2 Physik Nanoskaliger Systeme; ER-C-1 JCNS-FRM-II; JCNS-FRM-II Neutronenstreuung; JCNS-1 JARA-FIT; JARA-FIT Streumethoden; PGI-4 |
Published in: | Advanced materials, 33 (2021) 24, S. 2008683 |
Imprint: |
Weinheim
Wiley-VCH
2021
|
DOI: |
10.1002/adma.202008683 |
Document Type: |
Journal Article |
Research Program: |
Jülich Centre for Neutron Research (JCNS) (FZJ) Materials – Quantum, Complex and Functional Materials |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1002/adma.202008683 in citations.
Self-assembly of iron oxide nanoparticles (IONPs) into 1D chains is appealing, because of their biocompatibility and higher mobility compared to 2D/3D assemblies while traversing the circulatory passages and blood vessels for in vivo biomedical applications. In this work, parameters such as size, concentration, composition, and magnetic field, responsible for chain formation of IONPs in a dispersion as opposed to spatially confining substrates, are examined. In particular, the monodisperse 27 nm IONPs synthesized by an extended LaMer mechanism are shown to form chains at 4 mT, which are lengthened with applied field reaching 270 nm at 2.2 T. The chain lengths are completely reversible in field. Using a combination of scattering methods and reverse Monte Carlo simulations the formation of chains is directly visualized. The visualization of real-space IONPs assemblies formed in dispersions presents a novel tool for biomedical researchers. This allows for rapid exploration of the behavior of IONPs in solution in a broad parameter space and unambiguous extraction of the parameters of the equilibrium structures. Additionally, it can be extended to study novel assemblies formed by more complex geometries of IONPs. |