This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/28480 in citations.
Please use the identifier: http://dx.doi.org/10.1042/EBC20200134 in citations.
Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being
Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically...
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Personal Name(s): | Wolf, Sabrina |
---|---|
Becker, Judith / Tsuge, Yota / Kawaguchi, Hideo / Kondo, Akihiko / Marienhagen, Jan / Bott, Michael / Wendisch, Volker F. / Wittmann, Christoph (Corresponding author) | |
Contributing Institute: |
Biotechnologie; IBG-1 |
Published in: | Essays in biochemistry, 65 (2021) 2, S. 197 - 212 |
Imprint: |
London
Portland Press
2021
|
DOI: |
10.1042/EBC20200134 |
Document Type: |
Journal Article |
Research Program: |
Utilization of renewable carbon and energy sources and engineering of ecosystem functions |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1042/EBC20200134 in citations.
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange flavours, sun blockers, anti-ageing sugars, and polymers for regenerative medicine. Herein, we highlight recent advances in engineering of the microbe into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity. |