This title appears in the Scientific Report :
2021
Please use the identifier:
http://hdl.handle.net/2128/29040 in citations.
Please use the identifier: http://dx.doi.org/10.1002/hbm.25612 in citations.
Early motor network connectivity after stroke: An interplay of general reorganization and state‐specific compensation
Early motor network connectivity after stroke: An interplay of general reorganization and state‐specific compensation
Motor recovery after stroke relies on functional reorganization of the motor network, which is commonly assessed via functional magnetic resonance imaging (fMRI)-based resting-state functional connectivity (rsFC) or task-related effective connectivity (trEC). Measures of either connectivity mode hav...
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Personal Name(s): | Paul, Theresa |
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Hensel, Lukas / Rehme, Anne K. / Tscherpel, Caroline / Eickhoff, Simon B. / Fink, Gereon R. / Grefkes, Christian / Volz, Lukas J. (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 Kognitive Neurowissenschaften; INM-3 |
Published in: | Human brain mapping, 42 (2021) 16, S. 5230 - 5243 |
Imprint: |
New York, NY
Wiley-Liss
2021
|
PubMed ID: |
34346531 |
DOI: |
10.1002/hbm.25612 |
Document Type: |
Journal Article |
Research Program: |
Brain Dysfunction and Plasticity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1002/hbm.25612 in citations.
Motor recovery after stroke relies on functional reorganization of the motor network, which is commonly assessed via functional magnetic resonance imaging (fMRI)-based resting-state functional connectivity (rsFC) or task-related effective connectivity (trEC). Measures of either connectivity mode have been shown to successfully explain motor impairment post-stroke, posing the question whether motor impairment is more closely reflected by rsFC or trEC. Moreover, highly similar changes in ipsilesional and interhemispheric motor network connectivity have been reported for both rsFC and trEC after stroke, suggesting that altered rsFC and trEC may capture similar aspects of information integration in the motor network reflecting principle, state-independent mechanisms of network reorganization rather than state-specific compensation strategies. To address this question, we conducted the first direct comparison of rsFC and trEC in a sample of early subacute stroke patients (n = 26, included on average 7.3 days post-stroke). We found that both rsFC and trEC explained motor impairment across patients, stressing the clinical potential of fMRI-based connectivity. Importantly, intrahemispheric connectivity between ipsilesional M1 and premotor areas depended on the activation state, whereas interhemispheric connectivity between homologs was state-independent. From a mechanistic perspective, our results may thus arise from two distinct aspects of motor network plasticity: task-specific compensation within the ipsilesional hemisphere and a more fundamental form of reorganization between hemispheres. |