This title appears in the Scientific Report :
2022
Please use the identifier:
http://dx.doi.org/10.1016/j.neurobiolaging.2021.06.014 in citations.
Please use the identifier: http://hdl.handle.net/2128/32247 in citations.
Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease
Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease
Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia cannot be readily deduced from this binary classification. Here, we assesse...
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Personal Name(s): | Pfeil, Julia (Corresponding author) |
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Hoenig, Merle C. / Doering, Elena / van Eimeren, Thilo / Drzezga, Alexander / Bischof, Gerard Nisal / Initiative, Alzheimer's Disease Neuroimaging | |
Contributing Institute: |
Molekulare Organisation des Gehirns; INM-2 |
Published in: | Neurobiology of aging, 106 (2021) S. 119 - 129 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2021
|
DOI: |
10.1016/j.neurobiolaging.2021.06.014 |
Document Type: |
Journal Article |
Research Program: |
Neuroscientific Data Analytics and AI Neuroimaging |
Link: |
Restricted OpenAccess Restricted Restricted Restricted |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/32247 in citations.
Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia cannot be readily deduced from this binary classification. Here, we assessed if regional patterns of Aβ deposition measured with 18F-florbetapir may serve as biomarker for progression risk in Aβ-positive cognitively normal (CN) and MCI patients, including clinical follow-up data and cerebrospinal fluid (CSF) biomarkers. Voxel-wise group comparisons between age and sex-matched Aβ-positive groups (i.e., CN-stables [n = 38] vs. CN-to-MCI/AD progressors [n = 38], MCI-stables [n = 104] versus MCI-to-AD progressors [n = 104]) revealed higher Aβ burden in precuneus, subcortical, and parietal regions in CN-to-MCI/AD progressors and cingulate, temporal, and frontal regions in MCI-to-AD progressors. Importantly, these regional patterns predicted progression to advanced stages on the AD spectrum in the short and the long-term beyond global Aβ burden and CSF biomarkers. These results suggest that distinct regional patterns of Aβ burden are a valuable biomarker for risk of disease progression in CN and MCI. |