This title appears in the Scientific Report :
2022
Please use the identifier:
http://hdl.handle.net/2128/31094 in citations.
Please use the identifier: http://dx.doi.org/10.1002/smll.202106251 in citations.
Influence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulation
Influence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulation
Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2...
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Personal Name(s): | Sedlacek, Ondrej |
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Bardoula, Valentin / Vuorimaa-Laukkanen, Elina / Gedda, Lars / Edwards, Katarina / Radulescu, Aurel / Mun, Grigoriy A. / Guo, Yong / Zhou, Junnian / Zhang, Hongbo / Nardello-Rataj, Véronique / Filippov, Sergey / Hoogenboom, Richard (Corresponding author) | |
Contributing Institute: |
JCNS-4; JCNS-4 Neutronenstreuung; JCNS-1 Heinz Maier-Leibnitz Zentrum; MLZ JCNS-FRM-II; JCNS-FRM-II |
Published in: | Small, 18 (2022) 17, S. 2106251 |
Imprint: |
Weinheim
Wiley-VCH
2022
|
DOI: |
10.1002/smll.202106251 |
Document Type: |
Journal Article |
Research Program: |
Materials – Quantum, Complex and Functional Materials Jülich Centre for Neutron Research (JCNS) (FZJ) |
Subject (ZB): | |
Link: |
Get full text Published on 2022-02-25. Available in OpenAccess from 2023-02-25. |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1002/smll.202106251 in citations.
Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self-assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2-oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self-assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics. |