This title appears in the Scientific Report :
2022
Please use the identifier:
http://dx.doi.org/10.1016/j.cortex.2022.03.009 in citations.
Please use the identifier: http://hdl.handle.net/2128/31051 in citations.
Regional changes of brain structure during progression of idiopathic Parkinson's disease – A longitudinal study using deformation based morphometry
Regional changes of brain structure during progression of idiopathic Parkinson's disease – A longitudinal study using deformation based morphometry
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD are the degeneration of dopaminergic neurons in the striatum, and the propagation of aggregates of misfolded α-synucl...
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Personal Name(s): | Pieperhoff, Peter (Corresponding author) |
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Südmeyer, Martin / Dinkelbach, Lars / Hartmann, Christian J. / Ferrea, Stefano / Moldovan, Alexia S. / Minnerop, Martina / Diaz-Pier, Sandra / Schnitzler, Alfons / Amunts, Katrin | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 Jülich Supercomputing Center; JSC |
Published in: | Cortex, 151 (2022) S. 188 - 210 |
Imprint: |
New York, NY
Elsevier
2022
|
DOI: |
10.1016/j.cortex.2022.03.009 |
PubMed ID: |
35439717 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 3 Multilevel Brain Organization and Variability |
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/31051 in citations.
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD are the degeneration of dopaminergic neurons in the striatum, and the propagation of aggregates of misfolded α-synuclein in the brain following a specific pattern (Braak et al., 2006). The relationship of this pattern with motor and cognitive symptoms is still equivocal. Therefore, we investigated longitudinally the spatio-temporal patterns of atrophy propagation in PD, their inter-individual variability and associations with clinical symptoms. Magnetic resonance (MR) images of 37 PD patients and 27 controls were acquired at up to 15 time-points per subject, and over observation periods of up to 8.8 years (mean: 3.7 years). MR images were analyzed by Deformation-based Morphometry to measure region volumes and their longitudinal changes. Differences of these regional volume data between patients and controls and their associations with clinical symptoms were calculated. |