Progranulin [E-Book] : Methods and Protocols / edited by Andrew Bateman, Hugh P.J. Bennett, Siu Tim Cheung.
This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biolo...
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Full text |
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Personal Name(s): | Bateman, Andrew, editor |
Bennett, Hugh P.J., editor / Cheung, Siu Tim, editor | |
Imprint: |
New York, NY :
Humana Press,
2018
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Physical Description: |
XIII, 363 p. 79 illus., 56 illus. in color. online resource. |
Note: |
englisch |
ISBN: |
9781493985593 |
DOI: |
10.1007/978-1-4939-8559-3 |
Series Title: |
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Methods in Molecular Biology ;
1806 |
Subject (LOC): |
- A Brief Overview of Progranulin in Health and Disease
- Chromatographic Methods for the Purification of Granulin Peptides
- Methods for Expression and Purification of Biologically Active Recombinant Progranulin
- Large-Scale Generation of Recombinant Granulin Peptides in E. coli
- Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine Bridging
- Data Mining: Applying the AD&FTD Mutation Database to Progranulin
- Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human Diseases
- Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic Biomarker
- Analysis of Progranulin-Mediated Akt and MAPK Activation
- Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer Models
- Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell Features
- Methods to Study the Role of Progranulin in the Tumor Microenvironment
- Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegans
- The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response
- Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function
- Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice
- Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the Brain
- The Interaction between Progranulin with Sortilin and the Lysosome
- Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo Development
- Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory Arthritis
- Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro Studies
- Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models.