This title appears in the Scientific Report :
2013
On-chip optical stimulation and electrical recording from cells
On-chip optical stimulation and electrical recording from cells
We demonstrate an optoelectrical device capable of bidirectional optical stimulation and electrophysiological recording. It consists of an array of micropixellated InGaN light-emitting diodes coupled to a custom-made ultrathin planar microelectrode array. Electrogenic cells (HL-1) were transfected w...
Saved in:
Personal Name(s): | Yakushenko, Alexey |
---|---|
Maybeck, Vanessa / Boris, Hofmann / Gong, Zheng / Gu, Erdan / Dawson, Martin / Offenhäusser, Andreas / Wolfrum, Bernhard | |
Contributing Institute: |
JARA-FIT; JARA-FIT Bioelektronik; PGI-8 Bioelektronik; ICS-8 |
Imprint: |
2012
|
Conference: | 1st International Biophotonics Meeting in Israel, Tel Aviv (Israel), 2012-12-09 - 2012-12-11 |
Document Type: |
Poster |
Research Program: |
Sensorics and bioinspired systems Physics of the Cell Helmholtz Young Investigators Group |
Publikationsportal JuSER |
LEADER | 04104nam a2200673 a 4500 | ||
---|---|---|---|
001 | 141906 | ||
005 | 20210129213100.0 | ||
037 | |a FZJ-2014-00243 | ||
041 | |a English | ||
100 | 1 | |a Yakushenko, Alexey |0 P:(DE-Juel1)138367 |b 0 |u fzj | |
111 | 2 | |a 1st International Biophotonics Meeting in Israel |c Tel Aviv |d 2012-12-09 - 2012-12-11 |w Israel | |
245 | |a On-chip optical stimulation and electrical recording from cells | ||
260 | |c 2012 | ||
500 | |a The poster later resulted in a publication in the Journal of Biomedical Optics. | ||
520 | |a We demonstrate an optoelectrical device capable of bidirectional optical stimulation and electrophysiological recording. It consists of an array of micropixellated InGaN light-emitting diodes coupled to a custom-made ultrathin planar microelectrode array. Electrogenic cells (HL-1) were transfected with a light-sensitive protein and cultured directly on the chip. We monitored action potentials of individual spontaneously beating HL-1 cells by extracellular electrical recordings. On-chip light stimulation of non-beating HL-1 cells triggered network activity that was recorded using calcium imaging. We see the potential of our chip for electrophysiological experiments of optogenetically-modified cells with single cell resolution without complex optics or external light sources. | ||
700 | 1 | |a Maybeck, Vanessa |0 P:(DE-Juel1)128705 |b 1 |u fzj | |
700 | 1 | |a Boris, Hofmann |0 P:(DE-HGF)0 |b 2 | |
700 | 1 | |a Gong, Zheng |0 P:(DE-HGF)0 |b 3 | |
700 | 1 | |a Gu, Erdan |0 P:(DE-HGF)0 |b 4 | |
700 | 1 | |a Dawson, Martin |0 P:(DE-HGF)0 |b 5 | |
700 | 1 | |a Offenhäusser, Andreas |0 P:(DE-Juel1)128713 |b 6 |u fzj | |
700 | 1 | |a Wolfrum, Bernhard |0 P:(DE-Juel1)128745 |b 7 |u fzj | |
909 | C | O | |o oai:juser.fz-juelich.de:141906 |p VDB |
910 | 1 | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)138367 | |
910 | 1 | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)128705 | |
910 | 1 | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 6 |6 P:(DE-Juel1)128713 | |
910 | 1 | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-Juel1)128745 | |
913 | 1 | |a DE-HGF |b Schlüsseltechnologien |1 G:(DE-HGF)POF2-450 |0 G:(DE-HGF)POF2-453 |2 G:(DE-HGF)POF2-400 |v Physics of the Cell |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF2 |l BioSoft | |
913 | 1 | |a DE-HGF |b Schlüsseltechnologien |1 G:(DE-HGF)POF2-420 |0 G:(DE-HGF)POF2-423 |2 G:(DE-HGF)POF2-400 |v Sensorics and bioinspired systems |x 1 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF2 |l Grundlagen zukünftiger Informationstechnologien | |
914 | 1 | |y 2013 | |
980 | |a poster | ||
980 | |a VDB | ||
980 | |a I:(DE-Juel1)ICS-8-20110106 | ||
980 | |a I:(DE-Juel1)PGI-8-20110106 | ||
980 | |a I:(DE-82)080009_20140620 | ||
980 | |a UNRESTRICTED | ||
536 | |a Sensorics and bioinspired systems |0 G:(DE-HGF)POF2-423 |c POF2-423 |f POF II |x 2 | ||
536 | |a Physics of the Cell |0 G:(DE-HGF)POF2-453 |c POF2-453 |f POF II |x 1 | ||
536 | |a Helmholtz Young Investigators Group |0 G:(DE-HGF)HGF-YoungInvestigatorsGroup |c HGF-YoungInvestigatorsGroup |x 0 | ||
336 | |a CONFERENCE_POSTER |2 ORCID | ||
336 | |a conferenceObject |2 DRIVER | ||
336 | |a INPROCEEDINGS |2 BibTeX | ||
336 | |a Software |0 33 |2 EndNote | ||
336 | |a Poster |b poster |m poster |0 PUB:(DE-HGF)24 |s 1479375681_19620 |2 PUB:(DE-HGF) |x Other | ||
336 | |a Output Types/Conference Poster |2 DataCite | ||
981 | |a I:(DE-Juel1)IBI-3-20200312 | ||
920 | |l yes | ||
920 | |k JARA-FIT; JARA-FIT |0 I:(DE-82)080009_20140620 |l JARA-FIT |x 2 | ||
920 | |k Bioelektronik; PGI-8 |0 I:(DE-Juel1)PGI-8-20110106 |l Bioelektronik |x 1 | ||
981 | |a I:(DE-Juel1)PGI-8-20110106 | ||
920 | |k Bioelektronik; ICS-8 |0 I:(DE-Juel1)ICS-8-20110106 |l Bioelektronik |x 0 | ||
990 | |a Yakushenko, Alexey |0 P:(DE-Juel1)138367 |b 0 |u fzj | ||
991 | |a Wolfrum, Bernhard |0 P:(DE-Juel1)128745 |b 7 |u fzj | ||
991 | |a Offenhäusser, Andreas |0 P:(DE-Juel1)128713 |b 6 |u fzj | ||
991 | |a Dawson, Martin |0 P:(DE-HGF)0 |b 5 | ||
991 | |a Gu, Erdan |0 P:(DE-HGF)0 |b 4 | ||
991 | |a Gong, Zheng |0 P:(DE-HGF)0 |b 3 | ||
991 | |a Boris, Hofmann |0 P:(DE-HGF)0 |b 2 | ||
991 | |a Maybeck, Vanessa |0 P:(DE-Juel1)128705 |b 1 |u fzj |