This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.1098/rsfs.2010.0010 in citations.
Multi-frequency activation of neuronal networks by coordinated reset stimulation.
Multi-frequency activation of neuronal networks by coordinated reset stimulation.
We computationally study whether it is possible to stimulate a neuronal population in such a way that its mean firing rate increases without an increase of the population's net synchronization. For this, we use coordinated reset (CR) stimulation, which has previously been developed to desynchro...
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Personal Name(s): | Lysyansky, B. |
---|---|
Popovych, O.P. / Tass, P.A. | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Interface, 1 (2011) S. 75 - 85 |
Imprint: |
London
The Royal Society
2011
|
Physical Description: |
75 - 85 |
DOI: |
10.1098/rsfs.2010.0010 |
PubMed ID: |
22419975 |
Document Type: |
Journal Article |
Research Program: |
Theory, modelling and simulation Funktion und Dysfunktion des Nervensystems |
Series Title: |
Interface : Journal of the Royal Society
1 |
Subject (ZB): | |
Publikationsportal JuSER |
We computationally study whether it is possible to stimulate a neuronal population in such a way that its mean firing rate increases without an increase of the population's net synchronization. For this, we use coordinated reset (CR) stimulation, which has previously been developed to desynchronize populations of oscillatory neurons. Intriguingly, delivered to a population of predominantly silent FitzHugh-Nagumo or Hindmarsh-Rose neurons at sufficient stimulation amplitudes, CR robustly causes a multi-frequency activation: different Arnold tongues such as 1 : 1 or n : m entrained neuronal clusters emerge, which consist of phase-shifted sub clusters. Owing to the clustering pattern the neurons' timing is well balanced, so that in total there is no synchronization. Our findings may contribute to the development of novel and safe stimulation treatments that specifically counteract cerebral hypo-activity without promoting pathological synchronization or inducing epileptic seizures. |