This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1093/cercor/bhs048 in citations.
Please use the identifier: http://hdl.handle.net/2128/7431 in citations.
Organization of the Human Inferior Parietal Lobule Based on Receptor Architectonics
Organization of the Human Inferior Parietal Lobule Based on Receptor Architectonics
Human inferior parietal lobule (IPL) plays a key role in various cognitive functions. Its functional diversity, including attention, language, and action processing, is reflected by its structural segregation into 7 cytoarchitectonically distinct areas, each with characteristic connectivity patterns...
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Personal Name(s): | Caspers, S. |
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Schleicher, A. / Bacha-Trams, M. / Palomero-Gallagher, N. / Amunts, K. / Zilles, K. | |
Contributing Institute: |
Molekulare Organisation des Gehirns; INM-2 Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Cerebral cortex, 23 (2013) 3, S. 615-628 |
Imprint: |
Oxford
Oxford Univ. Press
2013
|
DOI: |
10.1093/cercor/bhs048 |
PubMed ID: |
22375016 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Cerebral Cortex
|
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/7431 in citations.
Human inferior parietal lobule (IPL) plays a key role in various cognitive functions. Its functional diversity, including attention, language, and action processing, is reflected by its structural segregation into 7 cytoarchitectonically distinct areas, each with characteristic connectivity patterns. We hypothesized that commonalities of the cytoarchitectonic, connectional, and functional diversity of the IPL should be reflected by a correlated transmitter receptor-based organization. Since the function of a cortical area requires a well-tuned receptor balance, the densities of 15 different receptors were measured in each IPL area. A hierarchical cluster analysis of the receptor balance revealed a tripartite segregation of the IPL into a rostral, middle, and caudal group. Comparison with other cortical areas showed strong similarities with Broca's region for all 3 groups, with the superior parietal cortex for the middle, and with extrastriate visual areas for the caudal group. Notably, caudal-most area PGp has a receptor fingerprint very similar to that of ventral extrastriate visual cortex. We therefore propose a new organizational model of the human IPL, consisting of 3 clusters, which corresponds to its known cytoarchitectonic, connectional, and functional diversity at the molecular level. This might reflect a general organizational principle of human IPL, beyond specific functional domains. |