This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1080/15548627.2015.1076605 in citations.
The mammalian autophagy initiator complex contains 2 HORMA domain proteins.
The mammalian autophagy initiator complex contains 2 HORMA domain proteins.
ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fol...
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Personal Name(s): | Michel, Max |
---|---|
Schwarten, Melanie / Decker, Christina / Nagel-Steger, Luitgard / Willbold, Dieter / Weiergräber, Oliver H. (Corresponding author) | |
Contributing Institute: |
Strukturbiochemie; ICS-6 |
Published in: | Autophagy, 11 (2015) 12, S. 2300 - 2308 |
Imprint: |
Abingdon, Oxon
Taylor & Francis
2015
|
PubMed ID: |
26236954 |
DOI: |
10.1080/15548627.2015.1076605 |
Document Type: |
Journal Article |
Research Program: |
Engineering Cell Function |
Publikationsportal JuSER |
ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fold. Both structural properties and biophysical evidence indicate that ATG101 is locked in this conformation, in contrast to the prototypical HORMA domain protein MAD2. Moreover, we discuss a potential mode of dimerization with ATG13 as a fundamental aspect of ATG101 function. |