This title appears in the Scientific Report :
2015
Please use the identifier:
http://hdl.handle.net/2128/19749 in citations.
Please use the identifier: http://dx.doi.org/10.1073/pnas.1510973112 in citations.
Physics of active jamming during collective cellular motion in a monolayer
Physics of active jamming during collective cellular motion in a monolayer
Although collective cell motion plays an important role, for example during wound healing, embryogenesis, or cancer progression, the fundamental rules governing this motion are still not well understood, in particular at high cell density. We study here the motion of human bronchial epithelial cells...
Saved in:
Personal Name(s): | Garcia, Simon |
---|---|
Hannezo, Edouard / Elgeti, Jens / Joanny, Jean-Francois / Silberzan, Pascal / Gov, Nir S. | |
Contributing Institute: |
Theorie der Weichen Materie und Biophysik; IAS-2 Theorie der Weichen Materie und Biophysik; ICS-2 |
Published in: | Proceedings of the National Academy of Sciences of the United States of America, 112 (2015) S. 15314-15319 |
Imprint: |
Washington, DC
National Acad. of Sciences
2015
|
PubMed ID: |
26627719 |
DOI: |
10.1073/pnas.1510973112 |
Document Type: |
Journal Article |
Research Program: |
Physical Basis of Diseases |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1073/pnas.1510973112 in citations.
LEADER | 05439nam a2200793 a 4500 | ||
---|---|---|---|
001 | 281437 | ||
005 | 20210129221738.0 | ||
024 | 7 | |a 10.1073/pnas.1510973112 |2 doi | |
024 | 7 | |a WOS:000366404200043 |2 WOS | |
024 | 7 | |a 2128/19749 |2 Handle | |
024 | 7 | |a altmetric:4882465 |2 altmetric | |
024 | 7 | |a pmid:26627719 |2 pmid | |
037 | |a FZJ-2016-01130 | ||
041 | |a English | ||
082 | |a 000 | ||
100 | 1 | |a Garcia, Simon |0 P:(DE-HGF)0 |b 0 | |
245 | |a Physics of active jamming during collective cellular motion in a monolayer | ||
260 | |a Washington, DC |c 2015 |b National Acad. of Sciences | ||
520 | |a Although collective cell motion plays an important role, for example during wound healing, embryogenesis, or cancer progression, the fundamental rules governing this motion are still not well understood, in particular at high cell density. We study here the motion of human bronchial epithelial cells within a monolayer, over long times. We observe that, as the monolayer ages, the cells slow down monotonously, while the velocity correlation length first increases as the cells slow down but eventually decreases at the slowest motions. By comparing experiments, analytic model, and detailed particle-based simulations, we shed light on this biological amorphous solidification process, demonstrating that the observed dynamics can be explained as a consequence of the combined maturation and strengthening of cell-cell and cell-substrate adhesions. Surprisingly, the increase of cell surface density due to proliferation is only secondary in this process. This analysis is confirmed with two other cell types. The very general relations between the mean cell velocity and velocity correlation lengths, which apply for aggregates of self-propelled particles, as well as motile cells, can possibly be used to discriminate between various parameter changes in vivo, from noninvasive microscopy data. | ||
700 | 1 | |a Hannezo, Edouard |0 P:(DE-HGF)0 |b 1 | |
700 | 1 | |a Elgeti, Jens |0 P:(DE-Juel1)130629 |b 2 |u fzj | |
700 | 1 | |a Joanny, Jean-Francois |0 P:(DE-HGF)0 |b 3 | |
700 | 1 | |a Silberzan, Pascal |0 P:(DE-HGF)0 |b 4 | |
700 | 1 | |a Gov, Nir S. |0 P:(DE-HGF)0 |b 5 | |
773 | |a 10.1073/pnas.1510973112 |0 PERI:(DE-600)1461794-8 |p 15314-15319 |t Proceedings of the National Academy of Sciences of the United States of America |v 112 |y 2015 |x 0027-8424 | ||
856 | 4 | |y OpenAccess |u http://juser.fz-juelich.de/record/281437/files/15314.full.pdf | |
856 | 4 | |y OpenAccess |x pdfa |u http://juser.fz-juelich.de/record/281437/files/15314.full.pdf?subformat=pdfa | |
909 | C | O | |o oai:juser.fz-juelich.de:281437 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
910 | 1 | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)130629 | |
913 | 1 | |a DE-HGF |b Key Technologies |l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |1 G:(DE-HGF)POF3-550 |0 G:(DE-HGF)POF3-553 |2 G:(DE-HGF)POF3-500 |v Physical Basis of Diseases |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 | |
914 | 1 | |y 2015 | |
915 | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record | ||
915 | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b P NATL ACAD SCI USA : 2014 | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection | ||
915 | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index | ||
915 | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded | ||
915 | |a National-Konsortium |0 StatID:(DE-HGF)0430 |2 StatID | ||
915 | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID | ||
915 | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b P NATL ACAD SCI USA : 2014 | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline | ||
915 | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List | ||
980 | 1 | |a FullTexts | |
980 | |a journal | ||
980 | |a VDB | ||
980 | |a UNRESTRICTED | ||
980 | |a I:(DE-Juel1)IAS-2-20090406 | ||
980 | |a I:(DE-Juel1)ICS-2-20110106 | ||
536 | |a Physical Basis of Diseases |0 G:(DE-HGF)POF3-553 |c POF3-553 |f POF III |x 0 | ||
336 | |a ARTICLE |2 BibTeX | ||
336 | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1454509846_9285 |2 PUB:(DE-HGF) | ||
336 | |a Output Types/Journal article |2 DataCite | ||
336 | |a article |2 DRIVER | ||
336 | |a Nanopartikel unedler Metalle (Mg0, Al0, Gd0, Sm0) |0 0 |2 EndNote | ||
336 | |a JOURNAL_ARTICLE |2 ORCID | ||
981 | |a I:(DE-Juel1)IBI-5-20200312 | ||
920 | |k Theorie der Weichen Materie und Biophysik; IAS-2 |0 I:(DE-Juel1)IAS-2-20090406 |l Theorie der Weichen Materie und Biophysik |x 0 | ||
981 | |a I:(DE-Juel1)ICS-2-20110106 | ||
920 | |k Theorie der Weichen Materie und Biophysik; ICS-2 |0 I:(DE-Juel1)ICS-2-20110106 |l Theorie der Weichen Materie und Biophysik |x 1 | ||
990 | |a Garcia, Simon |0 P:(DE-HGF)0 |b 0 | ||
991 | |a Gov, Nir S. |0 P:(DE-HGF)0 |b 5 | ||
991 | |a Silberzan, Pascal |0 P:(DE-HGF)0 |b 4 | ||
991 | |a Joanny, Jean-Francois |0 P:(DE-HGF)0 |b 3 | ||
991 | |a Elgeti, Jens |0 P:(DE-Juel1)130629 |b 2 |u fzj | ||
991 | |a Hannezo, Edouard |0 P:(DE-HGF)0 |b 1 |