This title appears in the Scientific Report :
2003
Please use the identifier:
http://dx.doi.org/10.1038/sj.npp.1300144 in citations.
Obsessive-compulsive disorder: Development of demand-controlled deep brain stimulation with methods from stochastic phase resetting
Obsessive-compulsive disorder: Development of demand-controlled deep brain stimulation with methods from stochastic phase resetting
Synchronization of neuronal firing is a hallmark of several neurological diseases. Recently, stimulation techniques have been developed which make it possible to desynchronize oscillatory neuronal activity in a mild and effective way, without suppressing the neurons' firing. As yet, these techn...
Saved in:
Personal Name(s): | Tass, P. A. |
---|---|
Klosterkötter, J. / Schneider, F. / Lenartz, D. / Koulousakis, A. / Sturm, V. | |
Contributing Institute: |
Institut für Medizin; IME |
Published in: | Neuropsychopharmacology, 28 (2003) S. s27 - s34 |
Imprint: |
London
Nature Publ. Group
2003
|
Physical Description: |
s27 - s34 |
PubMed ID: |
12827141 |
DOI: |
10.1038/sj.npp.1300144 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Neuropsychopharmacology
28 |
Subject (ZB): | |
Publikationsportal JuSER |
Synchronization of neuronal firing is a hallmark of several neurological diseases. Recently, stimulation techniques have been developed which make it possible to desynchronize oscillatory neuronal activity in a mild and effective way, without suppressing the neurons' firing. As yet, these techniques are being used to establish demand-controlled deep brain stimulation (DBS) techniques for the therapy of movement disorders like severe Parkinson's disease or essential tremor. We here present a first conceptualization suggesting that the nucleus accumbens is a promising target for the standard, that is, permanent high-frequency, DBS in patients with severe and chronic obsessive-compulsive disorder (OCD). In addition, we explain how demand-controlled DBS techniques may be applied to the therapy of OCD in those cases that are refractory to behavioral therapies and pharmacological treatment. |