This title appears in the Scientific Report :
2009
Please use the identifier:
http://dx.doi.org/10.1038/npp.2008.93 in citations.
Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia
Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia
Emotion discrimination deficits represent a well-established finding in schizophrenia. Although imaging studies addressed the cerebral dysfunctions underlying emotion perception in adult patients, the question of trait vs state characteristics is still unresolved. The investigation of juvenile patie...
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Personal Name(s): | Seiferth, N. Y. |
---|---|
Pauly, K. / Kellermann, T. / Shah, J. N. / Ott, G. / Herpertz-Dahlmann, B. / Kircher, T. / Schneider, F. / Habel, U. | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN |
Published in: | Neuropsychopharmacology, 34 (2009) S. 477 - 487 |
Imprint: |
London
Nature Publ. Group
2009
|
Physical Description: |
477 - 487 |
DOI: |
10.1038/npp.2008.93 |
PubMed ID: |
18580874 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Neuropsychopharmacology
34 |
Subject (ZB): | |
Publikationsportal JuSER |
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520 | |a Emotion discrimination deficits represent a well-established finding in schizophrenia. Although imaging studies addressed the cerebral dysfunctions underlying emotion perception in adult patients, the question of trait vs state characteristics is still unresolved. The investigation of juvenile patients offers the advantage of studying schizophrenia at an age where influences of illness course and long-term medication are minimized. This may enable a more detailed characterization of emotion discrimination impairments and their cerebral correlates with respect to their appearance and exact nature. A total of 12 juvenile patients with early onset schizophrenia and matched healthy juveniles participated in this study. fMRI data were acquired during an emotion discrimination task consisting of standardized photographs of faces displaying happy, sad, angry, fearful, or neutral facial expression. Similar to findings in adult patients, juvenile patients exhibited reduced performance specificity whereas sensitivity was unaffected. Independent of the valence, their processing of emotional faces was associated with hypoactivations in both fusiform gyri and in the left inferior occipital gyrus. In addition, hyperactivations in patients were found in the right cuneus common to happy, angry, and fearful faces. Further, most distinct changes were present in juvenile patients when processing sad faces. These results point to a dysfunction in cerebral circuits relevant for emotion processing already prominent in adolescent schizophrenia patients. Regions affected by a decrease in activation are related to visual and face processing, similar to deficits reported in adult patients. These changes are accompanied by hyperactivations in areas related to emotion regulation and attribution, possibly reflecting compensatory mechanisms. | ||
653 | 2 | 0 | |2 Author |a face |
653 | 2 | 0 | |2 Author |a emotion |
653 | 2 | 0 | |2 Author |a schizophrenia |
653 | 2 | 0 | |2 Author |a early onset |
653 | 2 | 0 | |2 Author |a fMRI |
653 | 2 | 0 | |2 Author |a adolescence |
650 | 2 | |2 MeSH |a Adolescent | |
650 | 2 | |2 MeSH |a Analysis of Variance | |
650 | 2 | |2 MeSH |a Brain: physiopathology | |
650 | 2 | |2 MeSH |a Brain Mapping | |
650 | 2 | |2 MeSH |a Discrimination (Psychology): physiology | |
650 | 2 | |2 MeSH |a Emotions | |
650 | 2 | |2 MeSH |a Facial Expression | |
650 | 2 | |2 MeSH |a Humans | |
650 | 2 | |2 MeSH |a Magnetic Resonance Imaging | |
650 | 2 | |2 MeSH |a Male | |
650 | 2 | |2 MeSH |a Reaction Time | |
650 | 2 | |2 MeSH |a Schizophrenia: physiopathology | |
650 | 2 | |2 MeSH |a Schizophrenic Psychology | |
650 | 2 | |2 MeSH |a Social Perception | |
650 | 2 | |2 MeSH |a Young Adult | |
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500 | |a This work was supported by the Federal Ministry of Education and Research ( Brain Imaging Center West, 01GO0204), the Research Center Julich, and the German Research Foundation (Schn 362/13-1 and 13-2). Ms Seiferth was supported by a fellowship for doctoral students of the German National Academic Foundation. We thank Volker Backes, Petra Engels, Ulrike Bowi, Sabrina Weber, Martina Reske, Kathrin Koch, Tony Stocker, Barbara Elghahwagi, Gaby Oefler, Andreas Lamerz, and Timo Vloet for their assistance and support as well as all participants and their parents. | ||
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