This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1007/s00203-008-0351-0 in citations.
Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability
Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability
SecA is a central component of the bacterial Sec preprotein translocase. Besides the housekeeping SecA (SecA1), some mostly pathogenic Gram-positive bacteria possess an accessory SecA (SecA2) that is involved in the export of a few substrates only. Here we show that neither of the two secA homologou...
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Personal Name(s): | Caspers, M. |
---|---|
Freudl, R. | |
Contributing Institute: |
Biotechnologie 1; IBT-1 |
Published in: | Archives of microbiology, 189 (2008) S. 605 - 610 |
Imprint: |
Berlin
Springer
2008
|
Physical Description: |
605 - 610 |
DOI: |
10.1007/s00203-008-0351-0 |
PubMed ID: |
18246326 |
Document Type: |
Journal Article |
Research Program: |
Biotechnologie |
Series Title: |
Archives of Microbiology
189 |
Subject (ZB): | |
Publikationsportal JuSER |
SecA is a central component of the bacterial Sec preprotein translocase. Besides the housekeeping SecA (SecA1), some mostly pathogenic Gram-positive bacteria possess an accessory SecA (SecA2) that is involved in the export of a few substrates only. Here we show that neither of the two secA homologous genes present in the genome of the non-pathogenic bacterium Corynebacterium glutamicum can be deleted, unless a copy of the respective gene is provided in trans on a plasmid. This finding is in marked contrast to all other cases examined so far making C. glutamicum the first reported bacterium possessing two essential SecA proteins. |