Description: LFP beta amplitude is linked to mesoscopic spatio-temporal phase patterns

This title appears in the Scientific Report : 2018

LFP beta amplitude is linked to mesoscopic spatio-temporal phase patterns

Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into planar waves. Here, we generalize this concept to additional classes of salient patterns that full...

Personal Name(s):	Denker, Michael (Corresponding author)
	Zehl, Lyuba / Kilavik, Bjørg E. / Diesmann, Markus / Brochier, Thomas / Riehle, Alexa / Grün, Sonja
Contributing Institute:	Computational and Systems Neuroscience; INM-6 Jara-Institut Brain structure-function relationships; INM-10 Theoretical Neuroscience; IAS-6
Published in:	Scientific reports, 8 (2018) 1, S. 5200
Imprint:	London Nature Publishing Group 2018
DOI:	10.1038/s41598-018-22990-7
PubMed ID:	29581430
Document Type:	Journal Article
Research Program:	Kognitive Leistung als Ergebnis koordinierter neuronaler Aktivität in unreifen präfrontal-hippokampalen Netzwerken Brain-inspired multiscale computation in neuromorphic hybrid systems The Human Brain Project Human Brain Project Specific Grant Agreement 1 Connectivity and Activity Kausative Mechanismen mesoskopischer Aktivitätsmuster in der auditorischen Kategorien-Diskrimination
Link:	Get full text Get full text OpenAccess OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://dx.doi.org/10.1038/s41598-018-22990-7 in citations.
Please use the identifier: http://hdl.handle.net/2128/20194 in citations.

Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into planar waves. Here, we generalize this concept to additional classes of salient patterns that fully describe the spatial organization of beta oscillations. During a delayed reach-to-grasp task we distinguish planar, synchronized, random, circular, and radial phase patterns in monkey primary motor and dorsal premotor cortices. We observe that patterns correlate with the beta amplitude (envelope): Coherent planar/radial wave propagation accelerates with growing amplitude, and synchronized patterns are observed at largest amplitudes. In contrast, incoherent random or circular patterns are observed almost exclusively when beta is strongly attenuated. The occurrence probability of a particular pattern modulates with behavioral epochs in the same way as beta amplitude: Coherent patterns are more present during movement preparation where amplitudes are large, while incoherent phase patterns are dominant during movement execution where amplitudes are small. Thus, we uncover a trigonal link between the spatial arrangement of beta phases, beta amplitude, and behavior. Together with previous findings, we discuss predictions on the spatio-temporal organization of precisely coordinated spiking on the mesoscopic scale as a function of beta power.