This title appears in the Scientific Report :
2020
Please use the identifier:
http://hdl.handle.net/2128/23923 in citations.
Please use the identifier: http://dx.doi.org/10.1093/neuonc/noz147 in citations.
Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: Response, Progression, and Pseudoprogression
Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: Response, Progression, and Pseudoprogression
The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT—either alone (especially ICI) or in combination with radiotherapy—imaging findings on anatomical contr...
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Personal Name(s): | Galldiks, Norbert (Corresponding author) |
---|---|
Kocher, Martin / Ceccon, Garry / Werner, Jan-Michael / Brunn, Anna / Deckert, Martina / Pope, Whitney B / Soffietti, Riccardo / Le Rhun, Emilie / Weller, Michael / Tonn, Jörg C / Fink, Gereon R / Langen, Karl-Josef | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 |
Published in: | Neuro-Oncology, 22 (2020) 1, S. 17-30 |
Imprint: |
Oxford
Oxford Univ. Press
2020
|
PubMed ID: |
31437274 |
DOI: |
10.1093/neuonc/noz147 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
Get full text Restricted Get full text Published on 2019-08-22. Available in OpenAccess from 2020-08-22. Published on 2019-08-22. Available in OpenAccess from 2020-08-22. Restricted |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1093/neuonc/noz147 in citations.
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520 | |a The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT—either alone (especially ICI) or in combination with radiotherapy—imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response. | ||
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