This title appears in the Scientific Report :
2022
Please use the identifier:
http://dx.doi.org/10.1007/s00259-022-05692-1 in citations.
Please use the identifier: http://hdl.handle.net/2128/31566 in citations.
Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s disease: a simultaneous PET/MR study
Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s disease: a simultaneous PET/MR study
Purpose: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are characterized by both aberrant regional neural activity and disrupted inter-regional functional connectivity (FC). However, the effect of AD/MCI on the coupling between regional neural activity (measured by regional fluor...
| Personal Name(s): | Maleki Balajoo, Somayeh |
|---|---|
| Rahmani, Farzaneh / Khosrowabadi, Reza / Meng, Chun / Eickhoff, Simon B. / Grimmer, Timo / Zarei, Mojtaba / Drzezga, Alexander / Sorg, Christian / Tahmasian, Masoud (Corresponding author) | |
| Contributing Institute: |
Molekulare Organisation des Gehirns; INM-2 Gehirn & Verhalten; INM-7 |
| Published in: | European journal of nuclear medicine and molecular imaging, 49 (2022) 9, S. 3173–3185 |
| Imprint: |
Heidelberg [u.a.]
Springer-Verl.
2022
|
| PubMed ID: |
35199225 |
| DOI: |
10.1007/s00259-022-05692-1 |
| Document Type: |
Journal Article |
| Research Program: |
Brain Dysfunction and Plasticity |
| Link: |
OpenAccess |
| Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/31566 in citations.
| LEADER | 06872nam a2201033 a 4500 | ||
|---|---|---|---|
| 001 | 906478 | ||
| 005 | 20230301071722.0 | ||
| 024 | 7 | |a 10.1007/s00259-022-05692-1 |2 doi | |
| 024 | 7 | |a 0340-6997 |2 ISSN | |
| 024 | 7 | |a 1432-105X |2 ISSN | |
| 024 | 7 | |a 1619-7070 |2 ISSN | |
| 024 | 7 | |a 1619-7089 |2 ISSN | |
| 024 | 7 | |a 2128/31566 |2 Handle | |
| 024 | 7 | |a altmetric:123582799 |2 altmetric | |
| 024 | 7 | |a pmid:35199225 |2 pmid | |
| 024 | 7 | |a WOS:000760059600001 |2 WOS | |
| 037 | |a FZJ-2022-01481 | ||
| 041 | |a English | ||
| 082 | |a 610 | ||
| 100 | 1 | |a Maleki Balajoo, Somayeh |0 P:(DE-Juel1)178767 |b 0 | |
| 245 | |a Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s disease: a simultaneous PET/MR study | ||
| 260 | |a Heidelberg [u.a.] |c 2022 |b Springer-Verl. | ||
| 520 | |a Purpose: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are characterized by both aberrant regional neural activity and disrupted inter-regional functional connectivity (FC). However, the effect of AD/MCI on the coupling between regional neural activity (measured by regional fluorodeoxyglucose imaging (rFDG)) and inter-regional FC (measured by resting-state functional magnetic resonance imaging (rs-fMRI)) is poorly understood.Methods: We scanned 19 patients with MCI, 33 patients with AD, and 26 healthy individuals by simultaneous FDG-PET/rs-fMRI and assessed rFDG and inter-regional FC metrics (i.e., clustering coefficient and degree centrality). Next, we examined the potential moderating effect of disease status (MCI or AD) on the link between rFDG and inter-regional FC metrics using hierarchical moderated multiple regression analysis. We also tested this effect by considering interaction between disease status and inter-regional FC metrics, as well as interaction between disease status and rFDG.Results: Our findings revealed that both rFDG and inter-regional FC metrics were disrupted in MCI and AD. Moreover, AD altered the relationship between rFDG and inter-regional FC metrics. In particular, we found that AD moderated the effect of inter-regional FC metrics of the caudate, parahippocampal gyrus, angular gyrus, supramarginal gyrus, frontal pole, inferior temporal gyrus, middle frontal, lateral occipital, supramarginal gyrus, precuneus, and thalamus on predicting their rFDG. On the other hand, AD moderated the effect of rFDG of the parietal operculum on predicting its inter-regional FC metric. | ||
| 588 | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de | ||
| 700 | 1 | |a Rahmani, Farzaneh |b 1 | |
| 700 | 1 | |a Khosrowabadi, Reza |b 2 | |
| 700 | 1 | |a Meng, Chun |b 3 | |
| 700 | 1 | |a Eickhoff, Simon B. |0 P:(DE-Juel1)131678 |b 4 | |
| 700 | 1 | |a Grimmer, Timo |b 5 | |
| 700 | 1 | |a Zarei, Mojtaba |b 6 | |
| 700 | 1 | |a Drzezga, Alexander |0 P:(DE-Juel1)177611 |b 7 | |
| 700 | 1 | |a Sorg, Christian |b 8 | |
| 700 | 1 | |a Tahmasian, Masoud |0 P:(DE-Juel1)188400 |b 9 |e Corresponding author | |
| 773 | |a 10.1007/s00259-022-05692-1 |0 PERI:(DE-600)2098375-X |n 9 |p 3173–3185 |t European journal of nuclear medicine and molecular imaging |v 49 |y 2022 |x 0340-6997 | ||
| 856 | 4 | |y Restricted | |
| 856 | 4 | |y OpenAccess |u http://juser.fz-juelich.de/record/906478/files/MalekiBalajoo2022_Article_DecouplingOfRegionalNeuralActi.pdf | |
| 909 | C | O | |o oai:juser.fz-juelich.de:906478 |p openaire |p open_access |p OpenAPC_DEAL |p driver |p VDB |p openCost |p dnbdelivery |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)178767 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 4 |6 P:(DE-Juel1)131678 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-Juel1)177611 | |
| 910 | 1 | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 9 |6 P:(DE-Juel1)188400 | |
| 913 | 1 | |a DE-HGF |b Key Technologies |l Natural, Artificial and Cognitive Information Processing |1 G:(DE-HGF)POF4-520 |0 G:(DE-HGF)POF4-525 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Decoding Brain Organization and Dysfunction |9 G:(DE-HGF)POF4-5252 |x 0 | |
| 914 | 1 | |y 2022 | |
| 915 | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-02-02 | ||
| 915 | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC | ||
| 915 | |a DEAL Springer |0 StatID:(DE-HGF)3002 |2 StatID |d 2021-02-02 |w ger | ||
| 915 | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-02-02 | ||
| 915 | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EUR J NUCL MED MOL I : 2021 |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-23 | ||
| 915 | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2022-11-23 | ||
| 915 | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-23 | ||
| 915 | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b EUR J NUCL MED MOL I : 2021 |d 2022-11-23 | ||
| 915 | p | c | |a APC keys set |2 APC |0 PC:(DE-HGF)0000 |
| 915 | p | c | |a Local Funding |2 APC |0 PC:(DE-HGF)0001 |
| 915 | p | c | |a DFG OA Publikationskosten |2 APC |0 PC:(DE-HGF)0002 |
| 915 | p | c | |a DEAL: Springer Nature 2020 |2 APC |0 PC:(DE-HGF)0113 |
| 980 | 1 | |a FullTexts | |
| 980 | |a journal | ||
| 980 | |a VDB | ||
| 980 | |a UNRESTRICTED | ||
| 980 | |a I:(DE-Juel1)INM-7-20090406 | ||
| 980 | |a I:(DE-Juel1)INM-2-20090406 | ||
| 980 | |a APC | ||
| 536 | |a Brain Dysfunction and Plasticity |0 G:(DE-HGF)POF4-5252 |c POF4-525 |f POF IV |x 0 | ||
| 336 | |a ARTICLE |2 BibTeX | ||
| 336 | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1658904019_15902 |2 PUB:(DE-HGF) | ||
| 336 | |a Output Types/Journal article |2 DataCite | ||
| 336 | |a article |2 DRIVER | ||
| 336 | |a Nanopartikel unedler Metalle (Mg0, Al0, Gd0, Sm0) |0 0 |2 EndNote | ||
| 336 | |a JOURNAL_ARTICLE |2 ORCID | ||
| 920 | |l yes | ||
| 920 | |k Molekulare Organisation des Gehirns; INM-2 |0 I:(DE-Juel1)INM-2-20090406 |l Molekulare Organisation des Gehirns |x 1 | ||
| 920 | |k Gehirn & Verhalten; INM-7 |0 I:(DE-Juel1)INM-7-20090406 |l Gehirn & Verhalten |x 0 | ||
| 991 | |a Tahmasian, Masoud |0 P:(DE-Juel1)188400 |b 9 |e Corresponding author | ||
| 991 | |a Sorg, Christian |b 8 | ||
| 991 | |a Drzezga, Alexander |0 P:(DE-Juel1)177611 |b 7 | ||
| 991 | |a Zarei, Mojtaba |b 6 | ||
| 990 | |a Maleki Balajoo, Somayeh |0 P:(DE-Juel1)178767 |b 0 | ||
| 991 | |a Grimmer, Timo |b 5 | ||
| 991 | |a Eickhoff, Simon |0 P:(DE-Juel1)131678 |b 4 | ||
| 991 | |a Meng, Chun |b 3 | ||
| 991 | |a Khosrowabadi, Reza |b 2 | ||
| 991 | |a Rahmani, Farzaneh |b 1 | ||