Structure and Function of GPCRs [E-Book] / edited by Guillaume Lebon.
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug disc...
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Full text |
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Personal Name(s): | Lebon, Guillaume, editor |
Edition: |
1st edition 2019. |
Imprint: |
Cham :
Springer,
2019
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Physical Description: |
XIV, 289 pages 71 illustrations, 52 illustrations in color (online resource) |
Note: |
englisch |
ISBN: |
9783030245917 |
DOI: |
10.1007/978-3-030-24591-7 |
Series Title: |
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Topics in Medicinal Chemistry ;
30 |
Subject (LOC): |
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field. |